Drug discovery Is changing. Drug development must change too.

· New Scientist

💬 Artificial intelligence and big data are flooding discovery pipelines with high-potential drug candidates, but this rapid innovation has created a new challenge. Simply put, our capability to design miracle molecules is vastly outstripping our technology to mass-manufacture them safely for the global public. Moving drug making from the scale of lab flasks to commercial bioreactors introduces non-linear biological and engineering shifts that can undermine tasks like purification.

Visit mwafrika.life for more information.

⚡In this New Scientist CoLab podcast, experts from global life sciences leader Cytiva explain the hidden, high-stakes science of purification that is required to close the gap between drug discovery and the pharmacy shelf.

Our guests are:

if( window?.adverts?.addToArray ) { window.adverts.addToArray( { "pos": "mid-article-slot" } ); }

Henrik Ihre, Distinguished Fellow, Cytiva

Paul Belcher, Business Leader, Cytiva

🎧 Stay tuned to learn about:

➡ The process of taking a drug from theoretical to the shop shelf

➡ How the drug purification works

➡ The human cost when purification goes wrong

➡ The challenges of keeping pace in manufacturing as AI supercharges drug discovery

Chapters:

(00:00) Intro – How drugs go from discovery to reality

(03:49) The purification process

(10:05) Why small scale success doesn’t mean industrial scale success

(13:00) The challenge of the expanding drug pipeline

(21:39) Understanding the molecules that are being purified

(23:20) What is a chromatography resin?

(25:24) Why purification gets more difficult later in the process

(27:15) The human impact when purification goes wrong

(32:59) The future of AI drug discovery

(37:52) Is AI helping with purification?

(40:32) How it feels to be advancing drug discovery

About the sponsor:

Cytiva: ⁠https://www.cytivalifesciences.com/ ⁠

About the podcast:

New Scientist CoLab explores the boundaries of innovation and the intersection of business, science and technology. Hosted by Justin Mullins.

Don’t miss an episode – subscribe now:

⁠https://www.youtube.com/@NewScientistCoLab⁠  

Connect with New Scientist:

Website: ⁠https://www.newscientist.com/⁠ 

Instagram: ⁠https://www.instagram.com/newscientist/⁠ 

Read full story at source